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The team developed the biosensors for several types of common drugs, such as cough suppressants and vasodilators, which are used to treat muscle spasms. The biosensors developed by dвЂ™Oelsnitz, Ellington and colleagues quickly and accurately determine the amount of a given molecule that a strain of bacteria is producing. вЂњWith this technique, it should be possible to create biosensors for a wide range of medicines.вЂќ

вЂњThere are currently no biosensors for most plant metabolites,вЂќ said Simon dвЂ™Oelsnitz, a research scientist in the Department of Molecular Biosciences and first author on the paper. Accurately analyzing the thousands of engineered strains on the way to a good producer can take weeks or months with current technology, but only a day with the new biosensors. Unfortunately, manufacturers have not had a way to quickly analyze different strains of engineered bacteria to identify the ones capable of producing quantities of a desired drug at commercial volumes-until now. And bacteria can replicate at high speed. In a process called biosynthesis, the bacteriaвЂ™s biological systems are harnessed to produce specific molecules as part of the natural cellular process.

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The genetic code of bacteria can be easily manipulated to become factories for drug production. Deriving similar therapeutic components using synthetic chemistry brings problems, too, since the process depends on petroleum and petroleum-based products linked to waste and expense.Д®nter the humble bacteria, a cheap, efficient, and sustainable alternative. And crops can be damaged by floods, fires, and drought. Extracting drugs from these plants is complicated and resource-intensive, requiring water and acreage to grow the crops. Many of the medicines we take are made with ingredients extracted from plants (think, for example, morphine, the narcotic painkiller that comes from poppies, or galantamine, a drug treatment for dementia that comes from daffodils).

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вЂњWeвЂ™re figuring out how to give bacteria вЂsenses,вЂ™ similar to olfactory receptors or taste receptors, and use them for detection of the various compounds they might make,вЂќ said Andrew Ellington, a professor of molecular biosciences and corresponding author on the paper.

coli bacteria, that can be adapted to detect all kinds of therapeutic compounds accurately and in mere hours. In a new paper out in Nature Chemical Biology ,В the UT Austin team introduces a biosensor system, derived from E. Using bacteria has been suggested as a good organic alternative, but detecting and optimizing the production of therapeutic molecules is difficult and time-consuming, requiring months at a stretch.

And thanks to a new bacterial tool developed by scientists at The University of Texas (UT) at Austin, the process of improving drug manufacturing in bacterial cells may be coming sooner than we thought.ДЇor decades, researchers have been eyeing ways to make drug manufacturing more affordable and sustainable than pharmaceutical makersвЂ™ current processes, many of which depend on either plant crops or petroleum. For more affordable, sustainable drug options than we have today, the medication we take to treat high blood pressure, pain, or memory loss may one day come from engineered bacteria, cultured in a vat like yogurt.